Interestingly, even crossing these mice with mice expressing the Neu oncogene in the mammary gland does not produce tumors more aggressive than those in mice expressing Neu alone Knudsen et al. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor and metastasize. How does cadherin switching influence cell behavior? Distinct cadherin profiles in special variant carcinomas and other tumors of the breast. Please log in to add an alert for this article. Specific cadherin family members influence growth-factor-receptor signaling and Rho GTPases to promote cell motility and invasion. Cell adhesion and drug resistance in cancer.
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Complex cadherin expression in human prostate cancer cells. Complex networks orchestrate epithelial-mesenchymal transitions. Shaping the vertebrate body plan by polarized embryonic cell movements. However, during progression to the neoplastic state, the cells show decreased N-cadherin expression and increased E-cadherin and P-cadherin expression; the E-cadherin might play a role in the initiation of the aberrant differentiation that characterizes ovarian carcinogenesis Patel, I. The cadherin cell-cell adhesion pathway in prostate cancer progression. Genetic dissection of cadherin function during nephrogenesis.
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Bruna verkoopt boeken en bloemen. N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. Effects of inappropriate cadherins N-cadherin promotes motility when expressed by epithelial cells De Wever et al. We are currently seeking proposals for four Workshops to be held in Uitschrijven kan met 1 klik. Development , Cytoskeleton 38 ,
Genetic dissection of cadherin function during nephrogenesis. When they restored normal pcatenin expression in SW48 cells, E-cadherin levels increased dramatically and the cells reverted from loosely connected colonies to the cobblestone-like colonies typical of epithelial cells. Changing neighbours, changing behaviour: Rho GTPases in cadherin-mediated phenotypic transformations N-cadherin in tumor cell interactions with endothelial cells N-cadherin in cell survival Therapeutic prospects Concluding remarks Acknowledgements References. Dagelijks tijdens de lunch het belangrijkste nieuws in je inbox? Inappropriate expression of R-cadherin or N-cadherin by a variety of cell types results in increased steady-state levels of active Rac1 and Cdc